Urolithiasis is a common urinary tract disorder affecting a large proportion of the global population and is characterized by a high rate of recurrence. The development of kidney stones is associated with several factors, including dietary habits, metabolic abnormalities, oxidative stress and urinary tract infections. Although surgical and pharmacological interventions are widely used for stone management, their long-term application is often limited by adverse effects, high treatment cost and the risk of stone reformation. In recent years, natural product-based polyherbal formulations have gained considerable attention as potential therapeutic alternatives due to their safety, affordability and multi-target pharmacological actions. These formulations combine different medicinal plants to produce synergistic effects that may inhibit crystal formation, enhance urine flow and provide renal protection. The present review summarizes current research on the preparation, phytochemical characterization and biological evaluation of polyherbal formulations with reported anti-urolithiatic activity. Experimental approaches used to assess crystal inhibition, antioxidant potential and diuretic effects are also discussed. In addition, challenges related to standardization, safety assessment and clinical validation of herbal combinations are highlighted. Overall, polyherbal formulations derived from natural products may offer promising opportunities for the development of effective and economical therapeutic strategies for the prevention and management of urolithiasis.