The monkeypox poxvirus is linked to smallpox and spreads via human-animal interaction. Previous smallpox protection provides minimal monkeypox protection. Slowly increasing monkeypox cases in Africa were generally ignored by the scientific community until last year, when more than 16,000 cases were recorded from nonendemic nations. WHO recently declared monkeypox a global health emergency. Although most instances are in males who have sex with other men, the disease threatens the whole population. A short feverish sickness with lymphadenopathy preceded the rash, which spreads radially outward. Recovery usually takes two to four weeks. Children, new parents, and those with weakened immune systems are prone to complications. PCR can diagnose viral DNA. Most treatment focuses on symptom relief. Tecorivimat is a good antiviral. High-risk populations, healthcare practitioners, and PCR labs should acquire smallpox immunizations. Symptom relief is usually enough. Tecorivimat fights viruses. Healthcare personnel and individuals in intimate social networks should be vaccinated against smallpox.