Marine plants and algae, in particular, are an uncharted territory in terms of resource potential for developing new bioactive compounds for introducing new drugs. Among these are peptides, lipids, polysaccharides, alkaloids, and polyphenols, which possess cancer fighting, bacteria killing, reducing inflammation and inflammation protecting, and nerve cell safeguarding abilities, among others. Organ sulfonates originating from the ocean are increasingly essential for expanding medicinal chemistry as structural motifs with remarkable properties since their chlorinated analogs. The recent advances in the genetic engineering and bioreactor systemization have brought the technology of utilizing marine life for various treatments to easier tracks, as in the recent past such compound production were done in a larger scale and sustainable way. In particular, algae express promising perspectives as the source of valuable bioactive chemicals regarded as an environmentally sustainable platform for drug development. Despite launch of dozens of drugs that Marine Bioactives inspired, there are challenges that span across multiple fields such as bioavailability, fetch, and reproducibility. The review provides information on contemporary developments in marine natural products for drug discovery. Included are the molecular aspects that render marine compounds bioactive, the results shown in clinical and preclinical studies of these compounds, and the identification of novel starting points via meantchology approaches such as computational aiding and omics. We emphasize the importance of sustainable use of the seas and colors cooperation with other fields while describing the great potential of medication created on the base of marine resources. Perhaps holding the key to better, less hazardous medication delivery, marine plants, and algae will become the stars of the field’s future treatments.