International Journal of

Pharmaceutical Science and Medicine

ISSN: 2584-1610 (Online)

International Journal of Pharmaceutical Science and Medicine

All Issues

1. ADVANCEMENTS IN UV-SPECTROSCOPY TECHNIQUES FOR SIMULTANEOUS QUANTIFICA...
14

Ravi Vishwakarma
Research Scholar, Faculty of Pharmacy, PK University, Thanra - 473665, Madhya Pradesh, India.

The simplicity, sensitivity, and cost-effectiveness of UV-spectroscopy have made it a major player in pharmaceutical analysis in recent years. Modern UV-spectroscopy methods developed for simultaneous quantification in pharmaceutical formulations are the focus of this systematic review, which seeks to provide a thorough overview of these developments. In order to provide light on significant trends and issues faced by the discipline, the study thoroughly examines advancements in instrumentation, technique, and practical applications. Highlighting developments in automation capabilities, sensitivity, and resolution, it delves into the evolution of UV-spectrophotometer instruments. The use of chemometrics and multivariate analytic methods to enable simultaneous quantification is the primary focus of the methodological breakthroughs examined. In addition, the paper explores practical uses of ultraviolet (UV) spectroscopy in the pharmaceutical industry, including examples of case studies of API and excipient quantification in different dosage forms. Also covered are the complexities of method validation and sample matrix effects, two of the limits and inherent constraints of UV-spectroscopy. Lastly, the study provides valuable insights into future prospects, touching on possible developments and developing technologies that might change the way pharmaceutical analysis uses UV-spectroscopy.

2. EXPLORING BIOACTIVE CONSTITUENTS: A REVIEW ON THE PHYTOCHEMICAL DIVERS...
5

Rishabh Gupta
Research Scholar, Faculty of Pharmacy, PK University, Thanra - 473665, Madhya Pradesh, India.

This paper investigates in detail the variety of phytochemicals found in different leaves that have been shown to have anti-diabetic properties. The ongoing worldwide health crisis of diabetes mellitus has prompted researchers to look for efficient treatment solutions, especially those derived from natural sources. Many plant species' leaves have been studied for their bioactive components that may influence how glucose is metabolised and lessen the symptoms of diabetes. The phytochemicals found in these leaves, including as flavonoids, alkaloids, terpenoids, and phenolic compounds, are the subject of contemporary study, which is summarised in this article. Furthermore, the processes that underlie their anti-diabetic activities are clarified, providing insight into their potential as therapeutic agents in the future. Our goal is to contribute to the development of new diabetes therapies by offering insightful information on the wide range of bioactive components present in leaves that have anti-diabetic qualities.

3. UNLOCKING THE COMBINED THERAPEUTIC POTENTIAL OF ALLIUM SATIVUM AND SWE...
10

Roshan Kumar Yadav
Research Scholar, Faculty of Pharmacy, PK University, Thanra - 473665, Madhya Pradesh, India.

This thorough analysis investigates the synergistic medicinal potential of Swertia chirata and Allium sativum (garlic) in treating oxidative stress and diabetic mellitus. Although both herbs have historically been used for medical purposes, new research indicates that using them together may have synergistic benefits. We provide an overview of the two plants' botanical descriptions and phytochemical compositions, emphasising important substances like flavonoids and allicin. Allium sativum and Swertia chirata are studied for their separate antioxidant and antidiabetic qualities, and then their synergistic benefits are examined. Discussion is held about the mechanisms that underlie synergy, such as improved bioavailability and complimentary routes. The review includes recommendations for future research areas and an evaluation of the clinical data supporting the combined use of these plants. The potential of synergistic plant combinations in the development of new antioxidant and antidiabetic medicines is highlighted in this study.

4. RECENT DEVELOPMENTS IN UV-SPECTROSCOPY TECHNIQUES FOR QUANTITATIVE ANA...
9

Ravindra Kumar Maurya
Research Scholar, Faculty of Pharmacy, PK University, Thanra - 473665, Madhya Pradesh, India.

Recent advances in UV-spectroscopy have significantly enhanced the quantitative assessment of pharmacological dosage forms by offering greater sensitivity and accuracy. This paper discusses recent developments in ultraviolet (UV) spectroscopy and how they affect drug analysis. Among the significant new advancements are nanotechnology, chemometrics, microfluidics, enhanced data processing, and smaller equipment. Scholars have used nanoparticles and nanocomposites to improve UV absorption and signal amplification. This makes selective detection possible even in complex matrices. The accuracy and resilience of data analysis and interpretation are increased by the use of chemometric techniques, such as principal component analysis and partial least squares. High-throughput analysis is possible with smaller sample volumes and less time needed thanks to miniature microfluidic technologies. Modern data processing techniques provide the possibility of spectrum analysis such as derivative spectroscopy and wavelet transform. A convenient and lightweight option for on-location analysis and point-of-care testing is the compact UV spectrophotometer. These developments have made UV spectroscopy essential for formulation development and quality control in the pharmaceutical sector. Two possible directions for the future are to better integrate these technologies for real-time analysis and to tackle novel issues in pharmaceutical analysis.

5. PHYTOCHEMISTRY AND PHARMACOLOGICAL DIVERSITY OF ACHYRANTHES ASPERA: A...
6

Sunil Kumar Kushwaha
Research Scholar, Faculty of Pharmacy, PK University, Thanra - 473665, Madhya Pradesh, India.

Traditional healers have long held the Achyranthes aspera, or "Prickly Chaff Flower," in high esteem due to its many medicinal uses. Achyranthes aspera is the subject of this comprehensive study, which seeks to understand the plant's complex phytochemistry and varied pharmacological effects. We find a wealth of bioactive chemicals in Achyranthes aspera, including alkaloids, flavonoids, saponins, and terpenoids, based on a comprehensive literature review that extends up to January 2024. These chemicals have a wide range of medicinal uses, including pain relief, hepatoprotective, anti-inflammatory, antioxidant, antibacterial, and antidiabetic actions. Our careful research reveals that Achyranthes aspera may have medicinal value in treating a wide range of diseases and ailments, including diabetes, arthritis, microbial infections, and liver issues. But our analysis not only reveals what is known now, but it also prepares the ground for such studies in the future. We encourage researchers to fully use Achyranthes aspera for the development of new therapeutic approaches by drawing attention to the need for further studies into the processes behind its therapeutic benefits. Our hope is that this extensive analysis will encourage further research and new ideas, raising awareness of Achyranthes aspera's potential as a therapeutic herb in contemporary medicine.

6. NANOTECHNOLOGY IN ANTIMICROBIAL THERAPY: ENHANCING THE ARSENAL AGAINST...
12

Jalaj Sonakpuri
Research Scholar, Institute of Pharmacy, Bundelkhand University, Jhansi-284128, Uttar Pradesh, India.

Antimicrobial resistance is a critical challenge for global health, weakening the use of most conventional antibiotics to treat infectious diseases. Recently, nanotechnological advancements have provided a new promise in the fight against resistant microorganisms and antimicrobial treatment support. This review provides an overview of nanotechnology for antimicrobial therapy, insights into the design and development of new classes of nanomaterials as well as drug delivery systems at nanoscale dimensions aimed towards various strategies targeting emerging MDR bacteria. Nanoparticles, nanostructures, nanosilver and nanoformulations have exhibited extensive prospect in ameliorating the drug stability, provocation of drug bioavailability and defeat the microbial resistance mechanism. Moreover, nanotechnology makes drugs more specific to the intended pharmaceutical target and less likely to affect other organs which subsequently improves therapeutic efficiency. The extraordinary properties of nanomaterials opened new doors for novel strategies against harmful microbes, e.g. antimicrobial surfaces and coatings. But there are technical issues to overcome related to safety, regulation and mass production. In this review, we address the recent progress in nanotechnology-based antimicrobial therapies and their mode of action to combat resistant microorganisms. Nanotechnology has the potential to significantly impact antimicrobial therapy with continued research and development, thereby enhancing our capability against the emergence of resistance to conventional antimicrobials.